By Gerhard Freund (auth.), Milton M. Gross (eds.)
Dr. Milton M. Gross, the editor of those volumes, died on July 29, 1976, after a quick sickness. As chairman of the part on Biomedical study in Alcoholism of the I.C.A.A., he had plan ned and taken to fruition the overseas "Symposium on Alcohol Intoxication and Withdrawal" which had taken position in Lausanne the month sooner than. He used to be quite happy with the celebrated crew of scientists he had helped to gather and used to be eagerly searching for ward to the e-book of those lawsuits which he was hoping could expand our figuring out of the phenomenology of alcoholism. Milton Gross was once a most original guy within the volume and variety of his actions and accomplishments. He was once a qualified psy chiatrist and psychoanalyst, a well-known scientific researcher, the writer of greater than fifty clinical papers, and the editor of 3 vital volumes on alcohol intoxication and withdrawal. He was once super lively within the clinical global of alcoholism as planner and coordinator of 3 overseas meetings, as chairman of the part on Biomedical study of the I.C.A.A., and as a member of a W.H.O. activity strength on Alcoholism. furthermore, he used to be very lively in a number of clinical and repair committees in nationwide and native organizations.
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Extra info for Alcohol Intoxication and Withdrawal—IIIb: Studies in Alcohol Dependence
Each data point is the mean of four observations in the 4-day fluctuating infusion condition, and six observations in the case of the 4-day constant infusion condition. :: I- o 120 » '0 ..... A. J. 001) for the two functions, respectively. Prior to BEC reaching zero, the mean tremor frequency is lower than control, which implies that ethanol tends to reduce physiological tremor. This finding is consistent with reports that human patients suffering from essential familial tremor frequently use alcoholic beverages to partially reduce the tremor they experience (Ashenhurst, 1973).
After most seizures, the cat regained consciousness immediately. With our treating method, 100% of the animals displayed this type of convulsion during the course of withdrawal. In the most severe cases, the animals continued to have periodic tonic-clonic convulsions every 3 to 10 minutes for many times an hour ("status"), as shown in this figure. The quantitative analysis of these convulsions is shown in the lower portion of the same figure. The closed circles represent the incidences and frequencies of isolated grand mal type convulsions and the stars represent the incidences and frequencies of "status" type convulsion.
Ethanol withdrawal syndrome in human subjects was studied under research ward conditions at the intramural laboratories of the National Institute on Alcohol Abuse and Alcoholism under the clinical supervision of Dr. H. Mendelson, and later under Dr. P. Steinglass. : Tamerin and Mendelson, 1969; Steinglass, Weiner and Mendelson, 1971; Majchrowicz and Mendelson, 1970, 1971; Ogata, Mendelson, Mello, and Majchrowicz, 1971). Here we will describe only those experimental parameters which were essential and similar to those used in the induction of ethanol dependence in rats or in other animals.
Alcohol Intoxication and Withdrawal—IIIb: Studies in Alcohol Dependence by Gerhard Freund (auth.), Milton M. Gross (eds.)